Author + information
- Received March 30, 2018
- Revision received April 26, 2018
- Accepted May 17, 2018
- Published online July 18, 2018.
- Robert Zilberszac, MD, PHDa,∗ (, )
- Georg Heinze, PHDb,
- Thomas Binder, MDa,
- Günther Laufer, MDc,
- Harald Gabriel, MDa and
- Raphael Rosenhek, MDa,∗ ()
- aDepartment of Cardiology, Medical University of Vienna, Vienna, Austria
- bCenter for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria
- cDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria
- ↵∗Address for correspondence:
Dr. Raphael Rosenhek, OR Dr. Robert Zilberszac, Department of Cardiology, Vienna General Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Objectives This study sought to assess the long-term outcome of active surveillance in these patients.
Background The optimal timing of mitral valve surgery in asymptomatic primary mitral regurgitation (MR) remains controversial.
Methods Between 1997 and 2015, 280 consecutive patients with severe asymptomatic primary MR were enrolled in our heart valve clinic follow-up program. They were prospectively followed up every 6 months clinical and echocardiographical examinations until surgical criteria were reached. Event-free survival and overall survival as compared with the age- and gender-matched general population were assessed.
Results During a median potential follow-up of 93.4 (quartiles 55.3 to 152.9) months, 161 patients developed an indication for surgery and 13 patients died. Event-free survival rates were 78.0% (95% confidence interval [CI]: 73.2% to 83.2%) at 2 years, 52.2% (95% CI: 46.3% to 59.0%) at 6 years, 35.5% (95% CI: 29.3% to 43.1%) at 10 years, and 18.7% (95% CI: 12.3% to 28.5%) at 15 years. Overall survival rate was 99.6% (95% CI: 98.9% to 100%) at 2 years, 94.6% (95% CI: 91.7% to 97.6%) at 6 years, 85.6% (95% CI: 80.3% to 91.2%) at 10 years, and 74.5% (95% CI: 66.6% to 83.4%) at 15 years. Overall survival of patients managed according to an active surveillance strategy was comparable with the expected cumulative survival and early survival rates were even better in the study population (standardized mortality ratio: 0.667; 95% CI: 0.463 to 0.963; p = 0.013).
Conclusions Patients with severe asymptomatic primary MR may remain free of indications for surgery for extensive periods of time. In such patients, active surveillance performed in experienced centers is associated with a favorable prognosis, resulting in timely referral to surgery, excellent long-term survival, and good surgical outcomes.
Dr. Laufer has done consulting activity for Edwards. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received March 30, 2018.
- Revision received April 26, 2018.
- Accepted May 17, 2018.
- 2018 American College of Cardiology Foundation
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