Author + information
- Received July 23, 2018
- Revision received August 21, 2018
- Accepted August 30, 2018
- Published online December 12, 2018.
- Sho Torii, MD, PhDa,
- Jihad A. Mustapha, MDb,
- Jagat Narula, MD, PhDc,
- Hiroyoshi Mori, MDa,
- Fadi Saab, MDb,
- Hiroyuki Jinnouchi, MDa,
- Kazuyuki Yahagi, MDa,
- Atsushi Sakamoto, MDa,
- Maria E. Romero, MDa,
- Navneet Narula, MDd,
- Frank D. Kolodgie, PhDa,
- Renu Virmani, MDa,∗ ( and )
- Aloke V. Finn, MDa
- aCVPath Institute, Gaithersburg, Maryland
- bAdvanced Cardiac and Vascular Amputation Prevention Centers, Grand Rapids, Michigan
- cIcahn School of Medicine at Mount Sinai, New York, New York
- dNew York University School of Medicine, New York, New York
- ↵∗Address for correspondence:
Dr. Renu Virmani, CVPath Institute, 19 Firstfield Road, Gaithersburg, Maryland 20878.
Objectives The aim of this study was to comprehensively evaluate the pathology of the lower extremity arteries across their entire length in subjects dying with abundant risk factors and to evaluate the clinical and imaging implications of the pathological characteristics.
Background Lower extremity peripheral arterial disease is a major cause of cardiovascular morbidity, but a systematic characterization of the pathology has never been undertaken.
Methods Twelve legs were obtained from 8 cadavers with histories of coronary risk factors (median age 82 years, 6 men); 8 of 12 legs were evaluated using computed tomography before the major peripheral arteries were dissected along their entire length. Dissected arteries were cut serially at 3 to 4 mm, and a total of 2,987 sections were examined.
Results Luminal irregularities and stenosis were more commonly seen in computed tomography images of above-the-knee (AK) arteries. Atherosclerotic lesions were histologically confirmed and were more common in AK (95.7%) than below-the-knee (BK) (56.8%) arteries. Occluded vessels were observed at 18 sites, including 8 AK and 10 BK arteries. Pathologically, acute thrombus was observed in all 8 AK sites, of which 3 were associated with plaque rupture and 5 were related to calcified nodules. The 10 occluded BK arteries revealed chronic total occlusions, of which half were embolic in origin and half were associated with atherosclerotic lesions. Intimal (75.3%) and medial (86.2%) calcifications were commonly encountered. Proportionate to the neointimal atherosclerosis, intimal calcification was more severe in AK arteries; the severity of medial calcification was no different between AK and BK arteries. Calcification was significantly greater in arteries excised from subjects with compared with those without diabetes.
Conclusions Atherosclerosis occurs more commonly in AK arteries and luminal occlusion from acute thrombosis secondary to rupture or calcified nodules. BK occlusion was chronic in nature, and at least half of lesions were embolic in origin. Medial calcification was similarly common in AK and BK arteries but more prevalent in subjects with diabetes.
- chronic total occlusion
- computed tomography angiography
- medial calcification
- peripheral artery disease
Drs. Torii and Mustapha contributed equally to this work and are joint first authors. Cardiovascular Systems, Inc. provided the funding for this study. Dr. Torii has received research grants from SUNRISE lab. Dr. Mustapha has received honoraria from Bard Peripheral Vascular, Boston Scientific, Cardiovascular Systems, Inc., Cook Medical, Medtronic, Spectranetics, and Terumo. Dr. Saab has received honoraria from Bard Peripheral Vascular, Boston Scientific, Cardiovascular Systems, Inc., Cook Medical, Medtronic, Spectranetics, and Terumo. Drs. Virmani and Finn have received institutional research support from Abbott Vascular, Boston Scientific, Cook Medical, Cardiovascular Systems, Inc., Medtronic, and Terumo. Dr. Virmani is a consultant for 480 Biomedical, Abbott Vascular, Medtronic, and W.L. Gore. All other authors have reported that they have no no relationships relevant to the contents of this paper to disclose.
- Received July 23, 2018.
- Revision received August 21, 2018.
- Accepted August 30, 2018.
- 2018 American College of Cardiology Foundation
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