Author + information
- Marwa Daghem, MBChBa,
- Rong Bing, MBBSa,
- Zahi A. Fayad, BSEE, MSE, PhDb,∗ ( and )
- Marc R. Dweck, BSc, MBChB, PhDa
- aBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
- bTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York
- ↵∗Address for correspondence:
Dr. Zahi A. Fayad, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, New York 10029.
• Assessment of coronary and carotid atherosclerotic plaque composition is possible using computed tomography and magnetic resonance imaging.
• Disease activity in coronary and carotid atherosclerotic plaque can be assessed using molecular imaging techniques, such as positron emission tomography.
• These imaging assessments of plaque type can be used to differentiate stable from unstable patterns of atherosclerosis and potentially to improve patient risk stratification.
Cardiovascular disease is one of the leading causes of mortality and morbidity worldwide. Atherosclerosis imaging has traditionally focused on detection of obstructive luminal stenoses or measurements of plaque burden. However, with advances in imaging technology it has now become possible to noninvasively interrogate plaque composition and disease activity, thereby differentiating stable from unstable patterns of disease and potentially improving risk stratification. This manuscript reviews multimodality imaging in this field, focusing on carotid and coronary atherosclerosis and how these novel techniques have the potential to complement current imaging assessments and improve clinical decision making.
Dr. Fayad is supported by National Institutes of Health/National Heart, Lung, and Blood Institute P01 HL131478, R01 HL071021, R01 HL128056, R01HL135878, R01HL144072, and R01HL143814; National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering R01 EB009638; and American Heart Association (14SFRN20780005). Dr. Dweck is supported by the Sir Jules Thorn Biomedical Research Award 2015 (15/JTA) and by the British Heart Foundation (FS/14/78/31020). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received October 5, 2018.
- Revision received March 7, 2019.
- Accepted March 24, 2019.
- 2019 The Authors