Table 1

Contraindications of Thrombolytic Therapy

Absolute ContraindicationRelative ContraindicationNo Contraindication
Left atrial thrombusActive peptic ulcerIsolated left atrial appendage thrombus
Recent (<3 weeks) ischemic strokeBlood pressure >180/110 mm HgAcute (<4 h) or previous (>3 weeks) ischemic stroke
Hemorrhagic strokeINR 2–3INR <2
Early (<4 days) post-operative periodRecent (<4 wk) internal bleedLate (>4 days) post-operative period
Traumatic accident <4 weeksPrevious SKZ therapy (5 days to 2 yrs)Pregnancy
Bleeding diathesisRecent CPR
Intracranial massInfective endocarditis
Active internal bleedHemorrhagic retinopathy
Aortic dissectionPericarditis

CPR = cardiopulmonary resuscitation; INR = international normalized ratio; SKZ = streptokinase.

  • Patients with hemorrhagic conversion of cerebral infarction on the neuroradiological study were not included.

  • INR levels represent the samples obtained at the time that the thrombolytic treatment decision was made. Thrombolytic agents were administered to the patients with an INR between 2 and 3 when the clinical setting was appropriate to avoid treatment delays.

  • Patients with acquired/congenital bleeding diathesis or an INR >3.