Table 2

Summary of Findings on Angina From Imaging Randomized Clinical Trials in Stable Ischemic Heart Disease

Trial Name (Ref. #)Target PopulationSAQ FindingsOther Symptom Findings
Improvement at Follow-upDifference by Randomization
CRESCENT (36)N = 350Both testing arms reported improvement in angina stability/frequency and disease perception at 1 yr1-yr improvement in angina frequency for coronary CTA vs. exercise ECG (p = 0.012) but not for other SAQ subscales1-yr angina-free rates: 39% for and 25% for coronary CTA vs. exercise ECG (p = 0.012)
CAPP (37)N = 488Both testing arms reported improvement in angina stability and frequency and QOL at 1 yr but no p values reported1-yr improvement in angina stability and QOL for coronary CTA vs. exercise ECG (p = 0.028, p = 0.041) but not for other SAQ subscales1-yr emergency department visit leading to hospitalization (p = 0.009) and CAD outpatient visit (p = 0.036) rates higher for exercise ECG vs. coronary CTA
PROMISE (35)N = 5,985Both testing arms reported significant improvements in SAQ subscales at 6 months and through 2 yrsNo difference by randomization across SAQ subscales through 2 yrs
SCOT-HEART (19)N = 4,146Both testing arms reported significant improvement in angina stability and frequency at 6 weeksNo difference by randomization in angina stability (p = 0.22) and frequency (p = 0.21) at 6 monthsNo difference by randomization in hospitalization for chest pain (p = 0.51)
WOMEN (33)N = 503Not reportedNot reported2-yr angina-free rates: 60% and 65% for exercise ECG vs. SPECT (p = 0.25)

CAPP = Cardiac CT for Assessment of Pain and Plaque; QOL = quality of life; SAQ = Seattle Angina Questionnaire; other abbreviations as in Table 1.