Table 3

Summary of Economic Evidence From Imaging Randomized Clinical Trials in Stable Ischemic Heart Disease

Trial AcronymTarget PopulationNear-Term Δ CostLong-Term Δ CostOverall Cost Findings
PROMISE (32)N = 9,504Δ $254 at 90-days (p = NS)Δ $627 at 3 yrs (p = NS)3-yr cumulative costs were $7,213 for coronary CTA vs. $6,586 for functional testing (p = NS)
SCOT-HEART (34)N = 4,146Index cost $342 higher for coronary CTA (p < 0.001)$462 at 6 months higher for coronary CTA (p < 0.0001)6-month cumulative costs were $1,900 for coronary CTA vs. $1,438 for SC (p < 0.0001); when excluding index coronary CTA cost, no differences in downstream costs: Δ $89 (p = 0.27)
CRESCENT (36)N = 350Index cost $164 higher for Selective coronary CTA€71 at 1 yr higher for exercise ECG (p < 0.0001)1-yr cumulative costs were €369 for coronary CTA vs. €440 for exercise ECG (p < 0.0001)
WOMEN (33)N = 824Index cost $341 higher for exercise SPECT (p < 0.001)$35 higher for exercise ECG (p = 0.0008)2-yr diagnostic procedural costs: $338 for exercise ECG vs. $643 for exercise SPECT (p < 0.001)

NS = not statistically significant; other abbreviations as in Table 1.