Table 5

Univariable and Multivariable Linear Regression Analysis to Examine the Association of Fibrosis Assessments With Functional Status

Univariable AnalysisMultivariable Analysis
Relative Change in 6-Min Walk (95% CI)p ValueModel 1 (ECV Fraction)Model 2 (Mid-Wall Fibrosis)
Relative Change in 6-Min Walk (95% CI)p ValueRelative Change in 6-Min Walk (95% CI)p Value
Age ≥70 yrs−50.3 (−83.0 to −17.6)0.003−41.4 (−74.5 to −8.36)0.01−50.3 (−83.0 to −17.7)0.003
Men−0.81 (−37.7 to 36.1)0.97−19.9 (−61.3 to 21.6)0.35−8.88 (−48.5 to 30.7)0.66
Peak aortic jet velocity, m/s−12.25 (−30.6 to 6.14)0.19−14.9 (−35.4 to 5.73)0.16−11.9 (−32.4 to 8.64)0.26
LVMi, g/m2−0.22 (−1.00 to 0.56)0.570.62 (−0.44 to 1.68)0.250.45 (−0.62 to 1.52)0.41
ECV fraction, %−9.09 (−15.4 to −2.81)0.005−9.77 (−17.0 to −2.58)0.01
Presence of mid−wall fibrosis−40.9 (−78.5 to −3.24)0.03−45.6 (−89.1 to −2.11)0.04

CI = confidence interval; other abbreviations as in Tables 2 and 3.