Table 2

Cardiovascular Magnetic Resonance Measures of Myocardial Fibrosis and Functional Status by Severity of Aortic Stenosis

Mild (n = 34)Moderate (n = 45)Severe (n = 87)p Value
Age, yrs67 (56−75)72 (66−77)71 (65−76)0.048
Men20 (59)32 (71)63 (72)0.33
EDVi, ml/m269 (60−77)68 (64−81)69 (61−79)0.72
End-systolic volume (indexed), ml/m224 (19−26)23 (20−27)22 (17−27)0.87
Stroke volume (indexed), ml/m247 (39−52)47 (42−56)47 (40−54)0.56
Systolic ejection fraction, %67 (63−69)66 (63−70)67 (63−72)0.65
Longitudinal function, mm13.6 ± 2.413.2 ± 2.911.2 ± 2.8<0.001
LVMi, g/m271 (61−86)87 (74−98)93 (80−104)<0.001
LVMi/EDVi, g/ml1.08 ± 0.201.21 ± 0.231.36 ± 0.28<0.001
Maximal myocardial wall thickness, mm8.2 ± 2.111.1 ± 3.313.4 ± 3.4<0.001
Mean myocardial wall thickness, mm5.9 ± 1.17.3 ± 1.68.7 ± 1.9<0.001
Patients with LVH6 (17)24 (53)59 (68)<0.001
Native myocardial T1, ms1,170 ± 301,180 ± 371,192 ± 460.02
20-min post-contrast myocardial T1, ms637 ± 45643 ± 48636 ± 450.73
Partition coefficient0.466 ± 0.030.466 ± 0.040.466 ± 0.050.07
ECV fraction, %27.8 ± 2.527.5 ± 2.027.8 ± 3.00.79
iECV, ml/m219.6 ± 4.622.9 ± 5.425.5 ± 8.1<0.001
Extracellular expansion (iECV ≥22.5 ml/m2)9 (26)23 (51)47 (54)0.021
Mid-wall late gadolinium enhancement2 (5.9)14 (31)28 (32)0.008
Diastolic function (E/e')11.1 (8.0−14.2)12.2 (10.1−16.4)13.5 (11.4−18.6)0.009
Natural log (hs troponin I)1.25 (0.72−1.55)1.76 (1.33−2.34)2.16 (1.59−2.81)<0.0001
6-min walk test, m420 (363−448)400 (340−450)390 (320−440)0.05

Values are median (interquartile range), n (%), or mean ± SD.

ECV = extracellular volume; LVH = left ventricular hypertrophy; other abbreviations as in Tables 1 and 2.