Table 5

Predictors of Cardiovascular Death at 1-Year Follow-Up

Univariate AnalysisMultivariable Analysis
HR (95% CI)p ValueHRadj (95% CI)Adjusted p Value
Age, yrs1.05 (1.02–1.09)0.0051.07 (1.03–1.11)0.001
Female2.16 (1.32–3.54)0.0021.74 (1.00–3.04)0.051
BMI ≤20 kg/m20.97 (0.96–0.98)<0.0010.99 (0.97–1.00)0.08
Cardiac risk factors
 Diabetes1.55 (1.06–2.27)0.021.75 (1.15–2.67)0.009
Past medical history
 History of CVEs1.52 (0.92–2.51)0.101.72 (1.03–2.87)0.04
Baseline cardiac rhythm
 Atrial fibrillation1.34 (0.83–2.17)0.230.16
Symptoms
 NYHA functional class III or IV1.78 (1.24–2.56)0.0020.11
Risk assessment
 Logistic EuroSCORE ≥40%2.93 (1.92–4.48)<0.0011.73 (1.05–2.86)0.03
LV systolic function
 LVEF, %1.47 (0.93–2.32)0.100.30
RV dysfunction3.05 (2.12–4.39)<0.0012.51 (1.64–3.86)<0.001
Procedural specifications
 Post-AR ≥moderate1.91 (1.15–3.15)0.012.02 (1.18–3.46)0.01

Multivariable model includes variables after stepwise inclusion using p < 0.10.

AR = aortic regurgitation; BMI = body mass index; CVE = cerebrovascular event; LVEF = left ventricular ejection fraction; other abbreviations as in Tables 1 and 4.

  • p value if added to multivariable model. Single imputation with the mode for missing data: n = 3 post-AR; n = 6 BMI ≤20 kg/m2; n = 2 NYHA functional class III or IV.