Table 4

Short- and Long-Term Clinical Outcomes According Presence or Absence of RVD

Normal RV Function (n = 791)RV Dysfunction (n = 325)Crude HR (95% CI)p ValueHRadj (95% CI)Adjusted p Value
30-day follow-up
 All-cause death21 (2.7)32 (9.9)3.86 (2.23–6.69)<0.0014.09 (2.33–7.18)<0.001
  Cardiovascular death17 (2.2)29 (9.0)4.32 (2.37–7.86)<0.0014.62 (2.51–8.50)<0.001
 Myocardial infarction6 (0.8)6 (1.9)2.46 (0.79–7.63)0.122.42 (0.76–7.68)0.13
 Cerebrovascular events
  Disabling stroke25 (3.2)8 (2.5)0.79 (0.35–1.74)0.550.80 (0.36–1.80)0.59
 MACCE41 (5.2)37 (11.4)2.24 (1.44–3.49)<0.0012.28 (1.45–3.59)<0.001
 Bleeding
  Life-threatening60 (7.6)37 (11.4)1.52 (1.01–2.29)0.0441.49 (0.98–2.26)0.06
  Major117 (14.8)52 (16.3)1.09 (0.78–1.51)0.621.08 (0.77–1.51)0.65
 Kidney injury
  Stage 319 (2.4)21 (6.6)2.76 (1.48–5.13)0.0012.43 (1.28–4.61)0.007
 Access site complications
  Major77 (9.8)36 (11.1)1.14 (0.77–1.70)0.511.14 (0.76–1.70)0.54
1-year follow-up
 All-cause death87 (11.1)83 (26.2)2.61 (1.93–3.53)<0.0012.48 (1.82–3.38)<0.001
  Cardiovascular death55 (7.1)62 (20.1)3.05 (2.12–4.39)<0.0012.94 (2.02–4.27)<0.001
 Myocardial infarction13 (1.7)11 (3.9)2.26 (1.01–5.05)0.0472.19 (0.97–4.97)0.06
 Cerebrovascular events
  Disabling stroke29 (3.7)12 (4.1)1.05 (0.53–2.05)0.901.00 (0.50–2.00)0.99
 MACCE115 (14.7)94 (29.6)2.20 (1.68–2.89)<0.0012.08 (1.57–2.76)<0.001

Values are number of first events (% from life table estimate) unless otherwise indicated. Hazard ratios (HRs) (95% confidence intervals [CIs]) are from Cox regressions for time-to-event data.

HRadj = adjusted hazard ratio; MACCE = major adverse cardiovascular and cerebrovascular events (composite of all-cause death, major stroke, and myocardial infarction); RVD = right ventricular dysfunction.

  • Adjusted effect of RV dysfunction using the covariates from the multivariable model indicated in Table 5 in case of more than 10 events reported overall.