Table 1

Overview of Studies Validating Various T1-Mapping Methods Against Histological Specimens

First Author (Ref. #)T1-Mapping MethodPatient Populationr and p Values
Flett et al. (8)EQ-CMR ECV18 AS and 8 HCM patientsr2 = 0.796, p < 0.001
Fontana et al. (33)ShMOLLI EQ ECV
Multiple breath-hold ECV
18 AS patientsr2 = 0.685, p < 0.001
r2 = 0.589, p < 0.001
White et al. (37)ShMOLLI single-bolus ECV
ShMOLLI EQ ECV
18 AS patientsr2 = 0.69, p < 0.001
r2 = 0.71, p < 0.001
Bull et al. (32)ShMOLLI native T119 AS patientsr = 0.655, p = 0.002
Miller et al. (36)DynEq-CMR MOLLI ECV6 Explanted heartsr2 = 0.893, p = 0.004
Iles et al. (34)Multiple breath-hold post contrast9 Patients with heart failure after orthotopic heart transplantationr = –0.70, p = 0.003
Mascherbauer et al. (13)Multiple breath-hold post contrast9 Patients with heart failure and preserved ejection fractionr = 0.977, p < 0.001
Iles et al. (35)Multiple breath-hold post contrast4 Explanted hearts;
8 patients with myectomy for HCM
r = −0.78, p = 0.003
Aus dem Siepen et al. (31)MOLLI ECV24 Patients with DCMr = 0.85, p < 0.01

AS = aortic stenosis; CMR = cardiac magnetic resonance; DCM = dilated cardiomyopathy; DynEq = dynamic equilibrium; ECV = extracellular volume; EQ = equilibrium; HCM = hypertrophic cardiomyopathy; (Sh)MOLLI = (shortened) modified Look-Locker inversion recovery sequence.