Table 3

Clinical Characteristics and Univariate Predictors of Events

HR (95% CI) for All Cardiac Eventsp ValueHR (95% CI) for Hard Cardiac Eventsp Value
Clinical characteristics
 Age1.04 (1.03–1.06)<0.00011.04 (1.02–1.05)<0.0001
 Male1.76 (1.28–2.42)0.00051.63 (1.08–2.44)0.02
 BMI1.03 (1.01–1.04)0.141.05 (1.03–1.07)0.09
 Diabetes2.77 (1.94–3.95)<0.00012.68 (1.76–4.07)<0.0001
 Hypercholesterolemia1.97 (1.46–2.65)<0.00011.76 (1.22–2.53)0.002
 Hypertension1.99 (1.45–2.72)<0.00012.12 (1.41–3.19)0.0003
 Family history of CAD0.99 (0.73–1.35)0.960.99 (0.68–1.43)0.98
 Smoking1.05 (0.76–1.44)0.791.00 (0.68–1.48)0.98
 Framingham risk score1.04 (1.03–1.05)<0.00011.05 (1.03–1.06)<0.0001
Pre-test likelihood of CAD
 Low0.62 (0.40–0.95)0.380.79 (0.55–1.12)0.18
 Moderate1.05 (1.04–1.06)0.021.01 (1.0–1.03)0.05
 High1.72 (1.26–2.35)0.00071.84 (1.28–2.65)0.001
Indications for CT
 Chest pain1.29 (1.01–1.64)0.051.22 (1.01–1.42)0.04
 Risk factors1.41 (1.04–1.79)0.0051.40 (1.02–1.72)0.01
 Positive stress test1.62 (1.17–2.27)0.0051.54 (1.11–2.13)0.005
Medical therapy
 ACE inhibitors1.32 (0.92–1.89)1.320.90 (0.61–1.56)0.9
 Nitrates1.90 (1.18–3.05)0.00861.52 (0.82–2.82)0.18
 Beta-blockers1.47 (1.08–2.02)0.01570.92 (0.6–1.40)0.69
 Aspirin1.98 (1.46–2.69)<0.00011.17 (0.79–1.74)0.44
 Diuretics1.72 (1.24–2.39)0.00131.69 (1.13–2.53)0.01
 AT1-blockers1.20 (1.00–1.44)0.051.06 (0.75–1.49)0.73
 Calcium-channel blockers1.52 (1.08–2.16)0.0181.35 (0.87–2.09)0.17
 Statins2.39 (1.78–3.22)<0.00011.73 (1.19–2.50)0.004

CI = confidence interval; HR = hazard ratio; other abbreviations as in Table 1.