Table 1

Demographic and Baseline Characteristics

Placebo (n = 32)LosmapimodTotal (n = 99)
LD (n = 33)HD (n = 34)
Demographics
 Male/female28/428/529/585/14
 Age, yrs63.7 ± 6.3765.3 ± 5.9462.3 ± 5.9063.8 ± 6.01
 Body mass index, kg/m228.9 ± 3.4428.0 ± 3.3529.8 ± 3.6828.9 ± 3.46
Medical history
 Current or ex-smoker22 (69)22 (67)27 (79)71 (72)
 Acute coronary syndrome or myocardial infarction17 (53)18 (55)22 (65)57 (58)
 Transient ischemic attack/stroke4 (13)10 (30)10 (29)24 (24)
 Peripheral vascular disease5 (16)3 (9)4 (12)12 (12)
 Type 2 diabetes mellitus3 (9)1 (3)2 (6)6 (6)
Concomitant medications
 Antiplatelet therapies28 (88)30 (91)29 (85)87 (88)
 ACEI or ARB22 (69)24 (73)26 (76)72(73)
 Beta-blockers18 (56)15 (45)22 (65)55 (56)
 Other antihypertensives15 (47)10 (30)14 (41)39 (39)
 Oral hypoglycemics2 (6)03 (9)5 (5)
Baseline values
 Systolic blood pressure, mm Hg130 (19)133 (16)135 (17)133 (17)
 Diastolic blood pressure, mm Hg76 (8)77 (11)79 (9)77 (9)
 Glucose, mmol/l5.81 (1.02)5.74 (0.60)5.99 (1.05)5.85 (0.90)
 Glucose, mg/dl104.60 (18.41)103.30 (10.82)107.80 (18.83)105.30 (16.27)
 Cholesterol, mmol/l4.20 (0.88)3.91 (0.75)3.71 (0.74)3.78 (0.94)
 Cholesterol, mg/dl150.97 (49.64)144.24 (28.76)143.24 (28.65)146.07 (36.41)
 HDL cholesterol, mmol/l1.23 (0.28)1.23 (0.32)1.16 (0.30)1.20 (0.30)
 HDL cholesterol, mg/dl47.49 (10.66)47.49 (12.39)44.79 (11.97)46.56 (11.59)
 LDL cholesterol, mmol/l2.22 (0.67)2.01 (0.51)1.91 (0.61)2.05 (0.59)
 LDL cholesterol, mg/dl85.71 (25.79)77.61 (19.85)74.32 (23.63)79.10 (22.96)
 Triglycerides, mmol/l1.63 (0.56)1.46 (0.74)1.40 (0.51)1.49 (0.60)
 Triglycerides, mg/dl144.25 (49.65)129.20 (65.66)123.89 (45.04)132.24 (53.58)
 hsCRP, mg/l1.00 (133)1.30 (146)1.30 (114)1.20 (122)
 Adiponectin, ng/ml11,219 (31)10,932 (45)10,110 (37)10,732 (38)

Values are mean ± SD or n (%).

ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker; HD = higher dose (losmapimod 7.5 mg twice daily); HDL = high-density lipoprotein; hsCRP = high-sensitivity C-reactive protein; LD = lower dose (losmapimod 7.5 mg once daily); LDL = low-density lipoprotein.

  • All patients were on statins for at least 3 months before the study.

  • hsCRP and adiponectin are reported as geometric mean (% coefficient of variation).

  • hsCRP values >10 mg/l were omitted.