Table 2

Univariable and Multivariable Analysis of Impact of AVA Calculated by Echocardiography or Computed Tomography on Mortality Under Medical Treatment in the Whole Cohort

IncrementAVAEchoAVACTp Value for Harrell C Index Comparison
HR (95%CI)p ValueHarrell
C Index
HR (95% CI)p ValueHarrell
C Index
Univariable−0.10 cm21.33 (1.20–1.49)<0.00010.8241.23 (1.14–1.33)<0.00010.8250.98
Multivariable1.26 (1.13–1.42)<0.00010.8021.18 (1.09–1.29)<0.00010.7990.96
UnivariableSpecific threshold6.90 (3.53–14.64)<0.00010.8425.32 (2.88–10.52)<0.00010.8450.94
Multivariable(1.0 and 1.2 cm2)4.67 (2.22–10.50)<0.00010.7933.16 (1.64–6.43)0.0050.8030.93
UnivariableSpecific threshold3.79 (2.20–6.58)<0.00010.7743.17 (1.82–5.56)<0.00010.7820.81
Multivariable(0.8 and 1.0 cm2)1.28 (0.78–2.45)0.311.43 (0.77–2.64)0.25

Multivariable analyses are adjusted for age-adjusted Charlson score index, sex, symptoms, mean gradient, and left ventricular ejection fraction.

AVA = aortic valve area; AVACT = aortic valve area calculated by computed tomography; AVAEcho = aortic valve area calculated by echocardiography; HR = hazard ratio; CI = confidence interval.

  • AVAEcho ≤1.0 cm2 and AVACT ≤1.2 cm2.

  • AVAEcho ≤0.8 cm2 and AVACT ≤1.0 cm2.