Table 1

Baseline Data of the Study Population

Total Population (N = 47)Biopsy-Negative (n = 22)Biopsy-Positive (n = 25)p Value
Age (yrs)62 [51 to 75]58 [49 to 69]66 [57 to 79]0.04
Male sex33 (70%)15 (68%)18 (70%)0.8
New York Heart Association functional class >II26 (55%)12 (55%)14 (56%)0.9
Brain natriuretic peptide level (pg/ml)563 [162 to 572]517 [99 to 608]607 [232 to 555]0.4
Diuretic use31 (66%)11 (50%)20 (80%)0.03
Beta-blocker use27 (57%)13 (59%)14 (56%)0.8
Glomerular filtration rate (ml/min/1.73 m2)75 [47 to 90]71 [48 to 95]75 [46 to 89]0.5
Low voltage on electrocardiogram (Carroll's criteria)27 (59%)12 (55%)15 (60%)0.6
Low voltage on electrocardiogram (Rahman's criteria)4 (9%)1 (5%)3 (13%)0.3
Atrial fibrillation8 (17%)4 (18%)4 (16%)0.8
Speckled appearance4 (9%)04 (16%)0.04
Left ventricular ejection fraction (%)55 [47 to 60]48 [45 to 55]52 [46 to 60]0.6
Interventricular septal thickness (cm)1.5 [1.1 to 1.9]1.3 [1.1 to 1.6]1.7 [1.4 to 2]0.004
Posterior wall thickness (cm)1.4 [1.1 to 1.6]1.2 [0.9 to 1.4]1.6 [1.2 to 1.9]0.001
Left ventricular mass (g)271 [195 to 351]232 [171 to 312]306 [210 to 363]0.03
Dilated left atrium (>20 cm2)30 (64%)15 (68%)15 (60%)0.7
Deceleration time (ms)172 [137 to 209]168 [120 to 205]176 [147 to 212]0.6
Deceleration time ≤150 ms14 (30%)6 (27%)8 (32%)0.5
E/E′ ratio >1518 (38%)8 (36%)10 (40%)0.7
Pseudonormal or restrictive diastology22 (47%)9 (41%)13 (50%)0.5
Myocardial performance index0.51 [0.29 to 0.71]0.46 [0.22 to 0.74]0.54 [0.40 to 0.70]0.2
Characteristic DHE on CMR22 (47%)3 (14%)19 (76%)<0.0001

Values are n [95% confidence interval] or n (%).

CMR = cardiac magnetic resonance; DHE = delayed hyper-enhancement.