Paul R. Scully, Elizabeth Morris, Kush P. Patel, Thomas A. Treibel, Maria Burniston, Ernst Klotz, James D. Newton, Nikant Sabharwal, Andrew Kelion, Charlotte Manisty, Simon Kennon, Muhiddin Ozkor, Michael Mullen, Neil Hartman, Perry M. Elliott, Francesca Pugliese, Philip N. Hawkins, James C. Moon and Leon J. Menezes
Planar and SPECT/CT Quantification in DPD Scintigraphy
Planar and single-photon emission computed tomography/computed tomography (SPECT/CT) quantification was performed retrospectively on 100 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scans. SPECT/CT quantification outperformed planar quantification and correlated with extracellular volume quantification by computed tomography (ECVCT). Differentiation of Perugini grade 2 and 3 was confounded by soft tissue uptake, which may be overcome by using a composite standardized uptake value (SUV) retention index, providing a potential novel biomarker for monitoring.