Author + information
- Received November 10, 2010
- Revision received January 14, 2011
- Accepted January 18, 2011
- Published online May 1, 2011.
- Benjamin J.W. Chow, MD⁎,†,⁎ (, )
- Osman Ahmed, BSc⁎,
- Gary Small, MBChB⁎,
- Abdul-Aziz Alghamdi, MBBS⁎,
- Yeung Yam, BSc⁎,
- Li Chen, MSc‡ and
- George A. Wells, PhD‡
- ↵⁎Reprint requests and correspondence:
Dr. Benjamin Chow, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada
Objectives We sought the incremental prognostic value of coronary computed tomography angiography (CTA) in coronary artery bypass graft (CABG) patients.
Background Coronary CTA is a noninvasive and accurate tool for the detection of obstructive coronary artery disease, and coronary CTA appears to have prognostic value in patients without previous revascularization. However, the prognostic value of coronary CTA to predict major adverse cardiac events in CABG patients is unclear.
Methods Consecutive CABG patients were prospectively enrolled and cardiac risk was calculated using the National Cholesterol Evaluation Program/Adult Treatment Panel III. Using the severity of native coronary artery disease and graft disease, the number of unprotected coronary territories (UCTs) (0, 1, 2, or 3) was calculated. Patients were followed for cardiac death and nonfatal myocardial infarction. All events were confirmed with death certificates or medical records and reviewed by a clinical events committee.
Results Between February 2006 and March 2009, 250 consecutive patients were enrolled and followed for a mean of 20.8 ± 10.1 months. At follow-up, 23 patients (9.2%) had major adverse cardiac events (15 cardiac deaths and 8 nonfatal MI). The absence of UCTs conferred a good prognosis with an annual event rate of 2.4%. Conversely, patients with 1, 2, and 3 UCTs had annualized event rates of 5.8%, 11.1%, and 21.7%, respectively. Multivariable analysis showed that UCTs (hazard ratio: 2.08; 95% confidence interval: 1.40 to 3.10; p < 0.001) was a predictor of major adverse cardiac events when adjusted for clinical variables. Examining the receiver-operator characteristic curves, the area under the curve increased from 0.61 to 0.76 when UCTs was combined with clinical variables (p = 0.001).
Conclusions Assessing UCTs with coronary CTA appears to have prognostic value in CABG patients and is incremental to clinical variables. Coronary CTA appears to be a promising tool for risk stratification of CABG patients. Further multicenter studies using large CABG cohorts are needed to confirm our findings.
- cardiac death
- computed tomography
- coronary angiography
- coronary artery bypass graft
- major adverse cardiac events
- myocardial infarction
This study was supported in part by the Imaging for Cardiovascular Therapeutics Project RE02-038 and the Canada Foundation for Innovation No. 11966. Dr. Chow is supported by CIHR New Investigator Award MSH-83718. He receives research support from GE Healthcare, Pfizer Inc., and AstraZeneca; fellowship training support from GE Healthcare; and educational support from TeraRecon Inc. The other authors have reported that they have no relationships to disclose.
- Received November 10, 2010.
- Revision received January 14, 2011.
- Accepted January 18, 2011.
- American College of Cardiology Foundation