Author + information
- Received August 10, 2011
- Revision received December 16, 2011
- Accepted December 22, 2011
- Published online September 1, 2012.
- Regina Moritz, MD⁎,
- Diane R. Eaker, MSEE⁎,
- Jill L. Anderson, BA⁎,
- Timothy L. Kline, MSEE⁎,
- Steven M. Jorgensen, BSEE⁎,
- Amir Lerman, MD† and
- Erik L. Ritman, MD, PhD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Erik L. Ritman, Professor, Physiology and Medicine, Department of Physiology and Biomedical Engineering, Alfred Building, 2-409, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55902
There is an increased body of evidence to suggest that the vasa vasorum play a major role in the progression and complications of vulnerable plaque leading to acute coronary syndrome. We propose that detecting changes in the flow in the vascular wall by intravascular ultrasound signals can quantify the presence of vasa vasorum. The results obtained in a porcine model of atherosclerosis suggest that intravascular ultrasound-based estimates of blood flow in the arterial wall can be used in vivo in a clinical research setting to establish the density of vasa vasorum as an indicator of plaque vulnerability.
This work was supported in part by National Institutes of Health Grant HL065342. All authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received August 10, 2011.
- Revision received December 16, 2011.
- Accepted December 22, 2011.
- American College of Cardiology Foundation